[HTML][HTML] Patient-derived colonoids from disease-spared tissue retain inflammatory bowel disease-specific transcriptomic signatures
TA Karakasheva, Y Zhou, HM Xie, GE Soto… - Gastro hep …, 2023 - Elsevier
Background and Aims A key histopathological feature of inflammatory bowel disease is
damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and
colonoids are a critical bench-to-bedside tool for studying the epithelium in inflammatory
bowel disease. The goal of the current study was to define transcriptional differences in
healthy versus diseased subjects that are sustained in enteroids and colonoids, including
from disease-spared tissue. Methods Biopsies and matching enteroid or colonoid cultures …
damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and
colonoids are a critical bench-to-bedside tool for studying the epithelium in inflammatory
bowel disease. The goal of the current study was to define transcriptional differences in
healthy versus diseased subjects that are sustained in enteroids and colonoids, including
from disease-spared tissue. Methods Biopsies and matching enteroid or colonoid cultures …
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