[HTML][HTML] Patient-derived tumor models and their distinctive applications in personalized drug therapy
J He, C Zhang, A Ozkan, T Feng, P Duan… - Mechanobiology in …, 2023 - Elsevier
Tumor models in vitro are conventional methods for developing anti-cancer drugs,
evaluating drug delivery, or calculating drug efficacy. However, traditional cell line-derived
tumor models are unable to capture the tumor heterogeneity in patients or mimic the
interaction between tumors and their surroundings. Recently emerging patient-derived
preclinical cancer models, including of patient-derived xenograft (PDX) model, circulating
tumor cell (CTC)-derived model, and tumor organoids-on-chips, are promising in …
evaluating drug delivery, or calculating drug efficacy. However, traditional cell line-derived
tumor models are unable to capture the tumor heterogeneity in patients or mimic the
interaction between tumors and their surroundings. Recently emerging patient-derived
preclinical cancer models, including of patient-derived xenograft (PDX) model, circulating
tumor cell (CTC)-derived model, and tumor organoids-on-chips, are promising in …
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