Pegylation increases platelet biocompatibility of gold nanoparticles

MJ Santos-Martinez, K Rahme… - Journal of …, 2014 - ingentaconnect.com
The increasing use of gold nanoparticles in medical diagnosis and treatment has raised the
concern over their blood compatibility. The interactions of nanoparticles with blood
components may lead to platelet aggregation and endothelial dysfunction. Therefore,
medical applications of gold nanoparticles call for increased nanoparticle stability and
biocompatibility. Functionalisation of nanoparticles with polythelene glycol (PEGylation) is
known to modulate cell-particle interactions. Therefore, the aim of the current study was to …

[PDF][PDF] PEGYLATION INCREASES PLATELET BIOCOMPATIBILITY OF GOLD NANOPARTICLES (13-518-R)

MJ Santos-Martinez, K Rahme, JJ Corbalana… - researchgate.net
The increasing use of gold nanoparticles in medical diagnosis and treatment has raised the
concern over their blood compatibility. The interactions of nanoparticles with blood
components may lead to platelet aggregation and endothelial dysfunction. Therefore,
medical applications of gold nanoparticles call for increased nanoparticle stability and
biocompatibility. Functionalisation of nanoparticles with polythelene glycol (PEGylation) is
known to modulate cell-particle interactions. Therefore, the aim of the current study was to …
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