METHODS: In a 6-week, randomized, double-blind, placebo-controlled trial at a single
academic center in the United States, individuals diagnosed with IBS (Rome IV criteria), with
moderate to severe symptoms based on the IBS Severity Scoring System (IBS-SSS score≥
175), were randomized to enteric-coated peppermint oil 180 mg 3 times daily vs placebo in
a 1: 2 ratio. The primary outcome was mean change in IBS-SSS scores from baseline to 6-
week endpoint. RESULTS: A modified intent-to-treat analysis revealed that there were …

Methods This article was identified as a potential PURL through the standard systematic
methodology that has been described here. An additional literature search was conducted
by searching UptoDate and PubMed with the terms IBS and peppermint oil, to find additional
literature to place this research into the context of current clinical practice.