Peptide agonist docking in the N-terminal ectodomain of a Class II G Protein-coupled receptor, the VPAC1 receptor: PHOTOAFFINITY, NMR, and MOLECULAR …
YV Tan, A Couvineau, S Murail, E Ceraudo… - Journal of Biological …, 2006 - ASBMB
The neuropeptide vasoactive intestinal peptide (VIP) strongly impacts on human
pathophysiology and does so through interaction with class II G protein-coupled receptors
named VIP pituitary adenylate cyclase-activating peptide (PACAP) receptors (VPACs). The
molecular nature of VIP binding to receptors remains elusive. In this work, we have docked
VIP in the human VPAC1 receptor by the following approach.(i) VIP probes containing
photolabile residues in positions 6, 22, and 24 of VIP were used to photolabel the receptor …
pathophysiology and does so through interaction with class II G protein-coupled receptors
named VIP pituitary adenylate cyclase-activating peptide (PACAP) receptors (VPACs). The
molecular nature of VIP binding to receptors remains elusive. In this work, we have docked
VIP in the human VPAC1 receptor by the following approach.(i) VIP probes containing
photolabile residues in positions 6, 22, and 24 of VIP were used to photolabel the receptor …
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