Persistent serum protein signatures define an inflammatory subcategory of long COVID
Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring
diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The
aetiologies may include persistent inflammation, unresolved tissue damage or delayed
clearance of viral protein or RNA, but the biological differences they represent are not fully
understood. Here we evaluate the serum proteome in samples, longitudinally collected from
55 PASC individuals with symptoms lasting≥ 60 days after onset of acute infection, in …
diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The
aetiologies may include persistent inflammation, unresolved tissue damage or delayed
clearance of viral protein or RNA, but the biological differences they represent are not fully
understood. Here we evaluate the serum proteome in samples, longitudinally collected from
55 PASC individuals with symptoms lasting≥ 60 days after onset of acute infection, in …
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