Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers
Aim To investigate the cytotoxic effect of Peruvoside and mechanism of action in human
cancers. Main methods Cell viability was measured by MTT assay and the cell cycle arrest
was identified by FACS. Real-time qPCR and western blotting studies were performed to
identify important gene and protein expressions in the different pathways leading to
apoptosis. Immunofluorescence was performed to understand protein localization and
molecular docking studies were performed to identify protein-ligand interactions. Key …
cancers. Main methods Cell viability was measured by MTT assay and the cell cycle arrest
was identified by FACS. Real-time qPCR and western blotting studies were performed to
identify important gene and protein expressions in the different pathways leading to
apoptosis. Immunofluorescence was performed to understand protein localization and
molecular docking studies were performed to identify protein-ligand interactions. Key …
Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers.
DR Dhanasekhar Reddy, RK Ranjith Kumavath… - 2020 - cabidigitallibrary.org
Aim: To investigate the cytotoxic effect of Peruvoside and mechanism of action in human
cancers. Main methods: Cell viability was measured by MTT assay and the cell cycle arrest
was identified by FACS. Real-time qPCR and western blotting studies were performed to
identify important gene and protein expressions in the different pathways leading to
apoptosis. Immunofluorescence was performed to understand protein localization and
molecular docking studies were performed to identify protein-ligand interactions. Key …
cancers. Main methods: Cell viability was measured by MTT assay and the cell cycle arrest
was identified by FACS. Real-time qPCR and western blotting studies were performed to
identify important gene and protein expressions in the different pathways leading to
apoptosis. Immunofluorescence was performed to understand protein localization and
molecular docking studies were performed to identify protein-ligand interactions. Key …
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