… methods to predict protein folding … drug discovery paradigm (named PPI-FIT) based on the
rationale of negatively regulating the level of a given protein by targeting folding intermediates…

… protein expression by targeting folding intermediates. Here, PPI-FIT was tested for the first
time on the cellular prion protein (… as prion diseases. We predicted the all-atom structure of an …

… protein levels by targeting folding intermediates. Here, PPI-FIT was tested for the first time on
the cellular prion protein … known as prion diseases. We predicted the all-atom structure of an …

… indicating that these protein folding intermediates could play … of protein expression to
diseaserelevant protein misfolding … Pharmacological inactivation of the prion protein by targeting …

… isomers of the cellular prion protein. Their unique biology, and … formation of these intermediates
in prion infection might lead … The possibility of the emergence of drug-resistant strains, by …

… binding to a PrP C folding intermediate and diverting it from the … folded domain of PrP C
may reduce the availability of unfolded PrP for prion propagation by acting as a pharmacological …

… as a pharmacological degrader for PrP by interfering with its … peptide, and even the prion
protein can display this particular … of rational drug design approaches to target prion propagation…

… for retention or restoration of normal physiological functionality of the target. In the case of …
Whether the folding intermediate of PrP (PrP i ) is merely the partially unfolded state (…

… to target prion protein and its pathogenic conversion. In the second part, we will discuss the
so-called multi-target drug … a novel target against prion diseases: a PrP-folding intermediate. …

… targets folding intermediates to modulate protein expression levels, thus opening new
opportunities for pharmacological … that has been shown to lower prion protein (PrP) levels, …