Background Pelvic, hip, and long bone fractures can result in significant bleeding at the time
of injury, with further blood loss if they are treated with surgical fixation. People undergoing
surgery are therefore at risk of requiring a blood transfusion and may be at risk of peri‐
operative anaemia. Pharmacological interventions for blood conservation may reduce the
risk of requiring an allogeneic blood transfusion and associated complications. Objectives
To assess the effectiveness of different pharmacological interventions for reducing blood …

… This review will focus on pharmacological interventions used to reduce bleeding during
surgery to rejoin fractured bones permanently (definitive fixation). … This review will aim to
assess the effectiveness of various pharmacological interventions to prevent blood loss
following definitive fixation of hip, pelvic and long bone fractures (definitive meaning a
permanent fix of the broken bone as opposed to a temporary surgery). Although emergency
blood transfusions provide a life‐saving treatment for people who have lost blood from …