Multidrug transporter over-expression is considered to limit access of antiepileptic drugs to
the epileptic focus region and to be one cause of intractable epilepsy. To reach further proof
for this multidrug transporter hypothesis, we compared P-glycoprotein expression rates in
subgroups of Wistar rats which are sensitive or resistant to the anticonvulsant effect of the
antiepileptic drug phenytoin in the amygdala-kindling model of temporal lobe epilepsy. In
the electrode-implanted amygdala of phenytoin-resistant rats, the area labelled for P …