Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut

SP Parsons, JD Huizinga - The Journal of physiology, 2018 - Wiley Online Library
The Journal of physiology, 2018Wiley Online Library
The gut is enmeshed by a number of cellular networks, but there is only a limited
understanding of how these networks generate the complex patterns of activity that drive gut
contractile functions. Here we review two fundamental types of cell behaviour, excitable and
oscillating, and the patterns that networks of such cells generate, trigger waves and phase
waves, respectively. We use both the language of biophysics and the theory of nonlinear
dynamics to define these behaviours and understand how they generate patterns. Based on …
Abstract
The gut is enmeshed by a number of cellular networks, but there is only a limited understanding of how these networks generate the complex patterns of activity that drive gut contractile functions. Here we review two fundamental types of cell behaviour, excitable and oscillating, and the patterns that networks of such cells generate, trigger waves and phase waves, respectively. We use both the language of biophysics and the theory of nonlinear dynamics to define these behaviours and understand how they generate patterns. Based on this we look for evidence of trigger and phase waves in the gut, including some of our recent work on the small intestine.
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