The objective of the research is to study antiproliferation activities (anti-breastcancer) of leaf extracts soursop (Annona muricata L.) from five locations growth in West Java, Indonesia against breast-cancer cell line Michigan Cancer Foundation-7 (MCF-7). Each of the soursop leaf from five locations, was extracted with 70% ethanol using a microwave as a tool for extraction. In vitro test against breast cancer cells growth was conducted using the MCF-7 cell line by means of the MTT-assay.. Based on the analysis of phytochemicals, all soursop leaf extracts contain alkaloids, triterpenoids, tannins, saponins and flavonoids, but did not contain any steroids compound. Soursop leaf extracts with the highest anticancer activity were derived from Sukabumi 1 with an IC50 value of 12.5 µg/ml. The results obtained from this study indicate the ability of soursop leaf extracts to inhibite the growth of breast cancer cells (MCF-7). Such extracts could be used in the treatment of cancer patients.