Piezo1 contributes to alveolar bone remodeling by activating β-catenin under compressive stress
Y Jiang, Y Chen, Y Lan, H Wang, T Li, Z Hu… - American Journal of …, 2024 - Elsevier
Introduction The mechanosensitive ion channel, Piezo1, is responsible for transducing
mechanical stimuli into intracellular biochemical signals and has been identified within
periodontal ligament cells (PDLCs). Nonetheless, the precise biologic function of Piezo1 in
the regulation of alveolar bone remodeling by PDLCs during compressive forces remains
unclear. Therefore, this study focused on elucidating the role of the Piezo1 channel in
alveolar bone remodeling and uncovering its underlying mechanisms. Methods PDLCs …
mechanical stimuli into intracellular biochemical signals and has been identified within
periodontal ligament cells (PDLCs). Nonetheless, the precise biologic function of Piezo1 in
the regulation of alveolar bone remodeling by PDLCs during compressive forces remains
unclear. Therefore, this study focused on elucidating the role of the Piezo1 channel in
alveolar bone remodeling and uncovering its underlying mechanisms. Methods PDLCs …
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