Pilot production of the recombinant peptide toxin of Heteractis crispa as a potential analgesic by intein-mediated technology
RS Esipov, DA Makarov, VN Stepanenko… - Protein Expression and …, 2018 - Elsevier
APHC3 is an analgesic polypeptide that was found in the sea anemone (Heteractis crispa),
and contains 56 amino acid residues. This polypeptide is of interest for the development of
medications for diseases, associated with inflammatory or neuropathological processes, as
well as its use as an analgesic. This work presents an innovative biotechnological method
for APHC3 production. We have constructed a recombinant plasmid intended for
biosynthesizing the fusion protein consisting of a chitin-binding domain, DnaB mini-intein …
and contains 56 amino acid residues. This polypeptide is of interest for the development of
medications for diseases, associated with inflammatory or neuropathological processes, as
well as its use as an analgesic. This work presents an innovative biotechnological method
for APHC3 production. We have constructed a recombinant plasmid intended for
biosynthesizing the fusion protein consisting of a chitin-binding domain, DnaB mini-intein …
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