Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents
A Mayence, JJV Eynde, L LeCour Jr, LA Walker… - European journal of …, 2004 - Elsevier
A Mayence, JJV Eynde, L LeCour Jr, LA Walker, BL Tekwani, TL Huang
European journal of medicinal chemistry, 2004•ElsevierA series of 13 1, 4-diarylpiperazines has been prepared, evaluated for antileishmanial
activity and their binding affinity to DNA was measured. Among these compounds, 1, 4-bis [4-
(1H-benzimidazol-2-yl) phenyl] piperazine (14) emerged as the most active compound with
an IC50 value of 0.41 μM which is about sevenfold more potent than pentamidine.
activity and their binding affinity to DNA was measured. Among these compounds, 1, 4-bis [4-
(1H-benzimidazol-2-yl) phenyl] piperazine (14) emerged as the most active compound with
an IC50 value of 0.41 μM which is about sevenfold more potent than pentamidine.
A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC50 value of 0.41 μM which is about sevenfold more potent than pentamidine.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果