Plasma Kallikrein and Angiotensin I-converting enzyme N-and C-terminal domain activities are modulated by the insertion/deletion polymorphism
Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules
involved in blood pressure regulation. In the last few years some polymorphisms of ACE
such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic
relevance is poorly understood. In addition, few studies investigated if the specific activity of
ACE domain is related to the I/D polymorphism and if it can affect other systems. The aim of
this study was to establish a biochemical and functional characterization of the I/D …
involved in blood pressure regulation. In the last few years some polymorphisms of ACE
such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic
relevance is poorly understood. In addition, few studies investigated if the specific activity of
ACE domain is related to the I/D polymorphism and if it can affect other systems. The aim of
this study was to establish a biochemical and functional characterization of the I/D …
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