Plasma lipid transfer proteins, high-density lipoproteins, and reverse cholesterol transport
▪ Abstract Cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP)
are members of the lipid transfer/lipopolysaccharide binding protein gene family. Recently,
the crystal structure of one of the members of the gene family, bactericidal permeability
increasing protein, was solved, providing potential insights into the mechanisms of action of
CETP and PLTP. These molecules contain intrinsic lipid binding sites and appear to act as
carrier proteins that shuttle between lipoproteins to redistribute lipids. The phenotype of …
are members of the lipid transfer/lipopolysaccharide binding protein gene family. Recently,
the crystal structure of one of the members of the gene family, bactericidal permeability
increasing protein, was solved, providing potential insights into the mechanisms of action of
CETP and PLTP. These molecules contain intrinsic lipid binding sites and appear to act as
carrier proteins that shuttle between lipoproteins to redistribute lipids. The phenotype of …
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