Plasmid-Mediated Transmission of KPC-2 Carbapenemase in Enterobacteriaceae in Critically Ill Patients
C Schweizer, P Bischoff, J Bender, A Kola… - Frontiers in …, 2019 - frontiersin.org
Carbapenem-resistant Enterobacteriaceae (CRE) cause health care-associated infections
worldwide, and they are of severe concern due to limited treatment options. We report an
outbreak of KPC-2-producing CRE that was caused by horizontal transmission of a
promiscuous plasmid across different genera of bacteria and hospitals in Germany. Eleven
isolates (8 Citrobacter freundii, 2 Klebsiella oxytoca, and 1 Escherichia coli) were obtained
from seven critically ill patients during the six months of the outbreak in 2016. One patient …
worldwide, and they are of severe concern due to limited treatment options. We report an
outbreak of KPC-2-producing CRE that was caused by horizontal transmission of a
promiscuous plasmid across different genera of bacteria and hospitals in Germany. Eleven
isolates (8 Citrobacter freundii, 2 Klebsiella oxytoca, and 1 Escherichia coli) were obtained
from seven critically ill patients during the six months of the outbreak in 2016. One patient …
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