Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase
Catabolism of galactose by Streptococcus pneumoniae alters the microbe's metabolism from
homolactic to mixed acid fermentation, and this shift is linked to the microbe's virulence.
However, the genetic basis of this switch is unknown. Pyruvate formate lyase (PFL) is a
crucial enzyme for mixed acid fermentation. Functional PFL requires the activities of two
enzymes: pyruvate formate lyase activating enzyme (coded by pflA) and pyruvate formate
lyase (coded by pflB). To understand the genetic basis of mixed acid fermentation …
homolactic to mixed acid fermentation, and this shift is linked to the microbe's virulence.
However, the genetic basis of this switch is unknown. Pyruvate formate lyase (PFL) is a
crucial enzyme for mixed acid fermentation. Functional PFL requires the activities of two
enzymes: pyruvate formate lyase activating enzyme (coded by pflA) and pyruvate formate
lyase (coded by pflB). To understand the genetic basis of mixed acid fermentation …
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