Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism
T Nomoto, Y Inoue, Y Yao, M Suzuki, K Kanamori… - Science …, 2020 - science.org
In the current clinical boron neutron capture therapy (BNCT), p-boronophenylalanine (BPA)
has been the most powerful drug owing to its ability to accumulate selectively within cancers
through cancer-related amino acid transporters including LAT1. However, the therapeutic
success of BPA has been sometimes compromised by its unfavorable efflux from cytosol due
to their antiport mechanism. Here, we report that poly (vinyl alcohol)(PVA) can form
complexes with BPA through reversible boronate esters in aqueous solution, and the …
has been the most powerful drug owing to its ability to accumulate selectively within cancers
through cancer-related amino acid transporters including LAT1. However, the therapeutic
success of BPA has been sometimes compromised by its unfavorable efflux from cytosol due
to their antiport mechanism. Here, we report that poly (vinyl alcohol)(PVA) can form
complexes with BPA through reversible boronate esters in aqueous solution, and the …
Poly (vinyl alcohol) boosting therapeutic potential of
T Nomoto, Y Inoue, Y Yao, M Suzuki, K Kanamori… - Science advances, 2019 - cir.nii.ac.jp
In the current clinical boron neutron capture therapy (BNCT), p-boronophenylalanine (BPA)
has been the most powerful drug owing to its ability to accumulate selectively within cancers
through cancer-related amino acid transporters including LAT1. However, the therapeutic
success of BPA has been sometimes compromised by its unfavorable efflux from cytosol due
to their antiport mechanism. Here, we report that poly (vinyl alcohol)(PVA) can form
complexes with BPA through reversible boronate esters in aqueous solution, and the …
has been the most powerful drug owing to its ability to accumulate selectively within cancers
through cancer-related amino acid transporters including LAT1. However, the therapeutic
success of BPA has been sometimes compromised by its unfavorable efflux from cytosol due
to their antiport mechanism. Here, we report that poly (vinyl alcohol)(PVA) can form
complexes with BPA through reversible boronate esters in aqueous solution, and the …
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