Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is a powerful tool in cancer imaging. The basic principle is the accumulation of the radiopharmaceutical in areas of increased glucose metabolism. However, glucose is also an important substrate for inflammatory cells. Recent studies suggested that PET/CT findings should be interpreted with caution in tuberculosis-endemic regions. 1, 2 Here we reported the images of two cases with pulmonary tuberculosis mimicking lung cancer. The first case was a 67-year-old female who was admitted with a history of cough and hemoptysis for the last 3 months. The computed tomography of thorax revealed a mass lesion in the left upper lobe of 4.1 cm× 4.5 cm in diameter. The maximum standardized uptake value (SUVmax) of the mass lesion was 13.6 on the PET/CT examination. Other case was a 68-year-old male patient who was admitted with a history of 2 months of cough. The thorax CT revealed a 4 cm× 2 cm mass lesion with spicular radiation in the left upper lobe