Genome editing is a modern technology for modifying or manipulating the genome. The initial molecular techniques like Zinc-Finger Nucleases (ZFNs) and Transcription Activator-Like Effector Nucleases (TALENs) had a relatively low resolution in a splicing site recognition and thus suffered from a lower specificity due to their off-target side effects. The contemporary method that involves Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) has recently gained a wide acceptance among researchers due to its speed, simplicity and ability for modifying genes. In this paper, the potential gain of genome editing with an accent on application in animal breeding will be discussed.