Potential neuroprotective effect of Anakinra in spinal cord injury in an in vivo experimental animal model
Objective: To evaluate the therapeutic effects of inhibiting interleukin-1 beta (IL-1β) in vivo
using Anakinra in an experimental model of spinal cord injury (SCI). Methods: All
experimental procedures were performed in the animal laboratory of Ankara Education and
Research Hospital, Ankara, Turkey between August 2012 and May 2014. The SCI was
induced by applying vascular clips to the dura via a 4-level T5-T8 laminectomy. Fifty-four rats
were randomized into the following groups: controls (n= 18), SCI+ saline (n= 18), and SCI+ …
using Anakinra in an experimental model of spinal cord injury (SCI). Methods: All
experimental procedures were performed in the animal laboratory of Ankara Education and
Research Hospital, Ankara, Turkey between August 2012 and May 2014. The SCI was
induced by applying vascular clips to the dura via a 4-level T5-T8 laminectomy. Fifty-four rats
were randomized into the following groups: controls (n= 18), SCI+ saline (n= 18), and SCI+ …
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