This paper summarizes work conducted at Pratt & Whitney to incorporate ANSYS Fluent into the computational fluid dynamics-based combustor design process. As a first step, turbulence, combustion and spray models that already exist and have been validated in the Pratt & Whitney legacy computational fluid dynamics (CFD) solver ALLSTAR were converted into user defined functions (UDFs) for usage with the core ANSYS Fluent solver. In this manner, a baseline solver was established that allowed a systematic testing of the ANSYS Fluent native models. The baseline solver was validated against computational results as well as experimental data obtained for (i) liquid jet in cross-flow (LJICF), (ii) ambient spray injector tests and (iii) Pratt & Whitney next generation product family configurations. These test cases established a thorough evaluation of ANSYS Fluent with UDFs on a spectrum of simple to complex geometries and flow physics relevant to the conditions encountered in aeroengine combustors. Results show that Fluent produces calculated results obtained by ALLSTAR with similar level of agreement to the experiments. Furthermore, Fluent provides better convergence compared to the legacy ALLSTAR solver with a similar computational resource requirement. The ANSYS Fluent native spray break-up models were also tested for the liquid jet in cross flow configuration, demonstrating the importance of modeling the stripping and primary break-up regime of a spray jet. This capability is currently available only via the use of UDFs.