Background and Aims Pancreatic cancer has the poorest 5-year survival rate of any major
solid tumor, but when diagnosed at an early stage, survival rates improve. Population
screening is impractical because pancreatic cancer is rare with a lifetime risk of 1.7%, but
accurate risk stratification in the general population could enable health care providers to
focus early detection strategies to at-risk individuals. Here, we validate a combined risk
prediction model that integrates a polygenic risk score and a clinical risk model. Methods …