Predicting distant metastasis and chemotherapy benefit in locally advanced rectal cancer
Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal
cancer. Adjuvant chemotherapy is usually used for distant control. However, not all patients
can benefit from adjuvant chemotherapy, and particularly, some patients may even get
worse outcomes after the treatment. We develop and validate an MRI-based radiomic
signature (RS) for prediction of DM within a multicenter dataset. The RS is proved to be an
independent prognostic factor as it not only demonstrates good accuracy for discriminating …
cancer. Adjuvant chemotherapy is usually used for distant control. However, not all patients
can benefit from adjuvant chemotherapy, and particularly, some patients may even get
worse outcomes after the treatment. We develop and validate an MRI-based radiomic
signature (RS) for prediction of DM within a multicenter dataset. The RS is proved to be an
independent prognostic factor as it not only demonstrates good accuracy for discriminating …
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