Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting
J Schmidt, AR Smith, M Magnin, J Racle, JR Devlin… - Cell Reports …, 2021 - cell.com
CD8+ T cell recognition of peptide epitopes plays a central role in immune responses
against pathogens and tumors. However, the rules that govern which peptides are truly
recognized by existing T cell receptors (TCRs) remain poorly understood, precluding
accurate predictions of neo-epitopes for cancer immunotherapy. Here, we capitalize on
recent (neo-) epitope data to train a predictor of immunogenic epitopes (PRIME), which
captures molecular properties of both antigen presentation and TCR recognition. PRIME not …
against pathogens and tumors. However, the rules that govern which peptides are truly
recognized by existing T cell receptors (TCRs) remain poorly understood, precluding
accurate predictions of neo-epitopes for cancer immunotherapy. Here, we capitalize on
recent (neo-) epitope data to train a predictor of immunogenic epitopes (PRIME), which
captures molecular properties of both antigen presentation and TCR recognition. PRIME not …
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