Predictive potential of head and neck squamous cell carcinoma organoids

SJ Hill, AD D'Andrea - Cancer Discovery, 2019 - AACR
SJ Hill, AD D'Andrea
Cancer Discovery, 2019AACR
In this issue of Cancer Discovery, Driehuis and colleagues establish culture conditions for
the rapid, efficient, and long-term expansion of healthy human oral mucosa and head and
neck squamous cell carcinoma (HNSCC) tumor organoids. The HNSCC tumor organoids
provide a functional platform for analyzing tumor cell phenotype, tumorigenic potential, and
drug and radiotherapy response, and they have a potential role in clinical decision-making.
See related article by Driehuis et al., p. 852.
Summary
In this issue of Cancer Discovery, Driehuis and colleagues establish culture conditions for the rapid, efficient, and long-term expansion of healthy human oral mucosa and head and neck squamous cell carcinoma (HNSCC) tumor organoids. The HNSCC tumor organoids provide a functional platform for analyzing tumor cell phenotype, tumorigenic potential, and drug and radiotherapy response, and they have a potential role in clinical decision-making.
See related article by Driehuis et al., p. 852.
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