Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: a pregnant dam mouse model
HS Singer, C Morris, C Gause, M Pollard… - Journal of …, 2009 - Elsevier
A pregnant mouse model was used to compare the effect of IgG, administered E13-E18,
from mothers of children with autistic disorder (MCAD), to controls (simple-and IgG-) on
behavioral testing in offspring. Mice, exposed in-utero to MCAD-IgG, as adolescents, were
more active during the first ten minutes of central field novelty testing and, as adults,
displayed anxiety-like behavior on a component of the elevated plus maze and had a
greater magnitude of startle following acoustic stimulation. On a social interaction paradigm …
from mothers of children with autistic disorder (MCAD), to controls (simple-and IgG-) on
behavioral testing in offspring. Mice, exposed in-utero to MCAD-IgG, as adolescents, were
more active during the first ten minutes of central field novelty testing and, as adults,
displayed anxiety-like behavior on a component of the elevated plus maze and had a
greater magnitude of startle following acoustic stimulation. On a social interaction paradigm …
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