Preparation and evaluation of 17-allyamino-17-demethoxygeldanamycin (17-AAG)-loaded poly(lactic acid-co-glycolic acid) nanoparticles

R Pradhan, BK Poudel, JY Choi, IS Choi… - Archives of pharmacal …, 2015 - Springer
… developed the novel 17-allyamino-17-demethoxygeldanamycin (17-AAG)-loaded poly(lactic …
The PLGA NPs were prepared by emulsification/solvent evaporation method. Both the drug/…

Formulation and in vitro evaluation of 17-allyamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric mixed micelles for glioblastoma multiforme

V Saxena, MD Hussain - Colloids and Surfaces B: Biointerfaces, 2013 - Elsevier
… 0.1 nm; drug loading was about 4.0 … 17-AAG-loaded mixed micelles to free 17-AAG. Due to
their targeting ability, size, high drug loading and controlled release behavior, 17-AAG loaded

Design and evaluation of micellar nanocarriers for 17-allyamino-17-demethoxygeldanamycin (17-AAG)

T Chandran, U Katragadda, Q Teng, C Tan - International journal of …, 2010 - Elsevier
formulation for 17-AAG, we attempted to incorporate 17-AAG … approximately doubled
the loading capacity for 17-AAG. PEG-… For instance, 17-AAG was incorporated into PEG-poly(d,l-…

17-Allylamino-17-demethoxygeldanamycin loaded PCL/PEG nanofibrous scaffold for effective growth inhibition of T47D breast cancer cells

S Talaei, H Mellatyar, Y Pilehvar-Soltanahmadi… - Journal of Drug Delivery …, 2019 - Elsevier
… 17AAG loaded PCL/PEG nanofibers (NFs) were prepared by … 17AAG was loaded into poly
(ɛ-caprolactone)/poly (ethylene … 17-DMAG (derivative of 17-AAG) could inhibit the growth of …

[HTML][HTML] 17-AAG

S Talaei, H Mellatyar, A Asadi, A Akbarzadeh… - histonemethyltransfsignal.com
… , we review preclinical and clinical research on 17-AAG as a … diblock composed of poly
(ethylene oxide)-b- poly(D,L-lactide) … et al. prepared 17-AAG and Fe3O4 loaded magnetic NPs …

Encapsulation of the HSP-90 chaperone inhibitor 17-AAG in stable liposome allow increasing the therapeutic index as assessed, in vitro, on Leishmania (L) …

ALOA Petersen, TA Campos, DAS Dantas… - Frontiers in cellular …, 2018 - frontiersin.org
… clinical trials, we prepared an inclusion complex … for evaluating leishmanicidal activity.
Treatment of infected macrophages with 0.006 nM of 17-AAG:HPβCD or 17-AAG:HPβCD-loaded

[HTML][HTML] Fabrication of Paclitaxel and 17AAG-loaded Poly-ε-Caprolactone Nanoparticles for Breast Cancer Treatment

YA Berko, AF Funmilola, EO Akala - Journal of pharmaceutics & …, 2021 - ncbi.nlm.nih.gov
… (poly-ε-caprolactone) nanoparticles in the delivery of 17-AAG – … The drug loaded nanoparticle
formulation also produced … A recent review highlights the extensive clinical evaluations

[PDF][PDF] Therapeutic Potential of Heat Shock Protein 90 Inhibitors, Geldanamycin, and Analog Compounds in Precision Cancer Therapy

AM Alzebari, AM Qadir, MS Rafaat… - BioMed Target Journal, 2023 - researchgate.net
17-allyamino-17demethoxygeldanamycin (17-AAG)-loaded poly (lactic acid-co-glycolic
acid) … Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) …

Hyaluronic acid-decorated poly (lactic-co-glycolic acid) nanoparticles for combined delivery of docetaxel and tanespimycin

R Pradhan, T Ramasamy, JY Choi, JH Kim… - Carbohydrate …, 2015 - Elsevier
evaluate the cellular uptake of HA-PLGA NPs, they were prepared and loaded with DTX,
17-AAG, … In this study, dual drug DTX/17-AAG-loaded HA-decorated PLGA NPs were prepared

Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated …

N Sain, B Krishnan, MG Ormerod, A De Rienzo… - Molecular cancer …, 2006 - AACR
… In conclusion, 17-AAG may sensitize a subset of ovarian … in PBS (Sigma) in
preparation for flow cytometric analysis using the … transduction by 17-allyamino-17-demethoxygeldanamycin, …