Preparation and statistical optimization of Losartan Potassium loaded nanoparticles using Box Behnken factorial design: Microreactor precipitation
The current study deals with the development and optimization of Losartan Potassium (LP)
loaded nanoparticles by continuous flow microreactor precipitation methodology for
sustained release. Formulation of LP loaded nanoparticles was conducted by using box
Behnken (3 3) experimental design to evaluate the effect of three independent process
variables viz., polymer concentration (Ethyl cellulose, X 1), surfactant concentration (Tween
80, X 2) and the inner diameter (X 3) of the microreactor on the preferred responses …
loaded nanoparticles by continuous flow microreactor precipitation methodology for
sustained release. Formulation of LP loaded nanoparticles was conducted by using box
Behnken (3 3) experimental design to evaluate the effect of three independent process
variables viz., polymer concentration (Ethyl cellulose, X 1), surfactant concentration (Tween
80, X 2) and the inner diameter (X 3) of the microreactor on the preferred responses …
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