Background: The burnout syndrome is significant problem in modern working environtment and its prevalence has increased substantially. Objectives: This systematic review aimed to evaluate the literature on reducing nurse burnout, to estimate the prevalence of burnout, to identify the variables related to burnout and to propose a risk profile for this syndrome among the nursing. Methods: We identified articles through databases searching: Sage, Proquest, Science Direct, Springerlink, and EbscoHost, published between 2006-2016, search terms include various combination of the terms “Burnout Syndrome”, and “nursing”. Result: Five studies were included in this review. The prevalence of burnout among nursing professionals is high. Personal factors such as demographic variables, personal stress, and personality characteristics were predictive of burnout. Work related factors such as work stress, work environment, job characteristics and organizational variables were also found to be determinants of burnout in this population. Conclusion: The prevalence of burnout among nursing professionals is high. Personal stress, job satisfaction, work stress, quality of care, work environment are determinants of burnout. As a consequence specific action targets for hospital management are formulated to prevent burnout in nurses. Nurse staffing strategies need to be evaluated within developing context to ascertain in their effectiveness.