Prevention of oxidant-induced cell death by lysosomotropic iron chelators
HL Persson, Z Yu, O Tirosh, JW Eaton… - Free Radical Biology and …, 2003 - Elsevier
Intralysosomal iron powerfully synergizes oxidant-induced cellular damage. The iron
chelator, desferrioxamine (DFO), protects cultured cells against oxidant challenge but
pharmacologically effective concentrations of this drug cannot readily be achieved in vivo.
DFO localizes almost exclusively within the lysosomes following endocytic uptake,
suggesting that truly lysosomotropic chelators might be even more effective. We
hypothesized that an amine derivative of α-lipoamide (LM), 5-[1, 2] dithiolan-3-yl-pentanoic …
chelator, desferrioxamine (DFO), protects cultured cells against oxidant challenge but
pharmacologically effective concentrations of this drug cannot readily be achieved in vivo.
DFO localizes almost exclusively within the lysosomes following endocytic uptake,
suggesting that truly lysosomotropic chelators might be even more effective. We
hypothesized that an amine derivative of α-lipoamide (LM), 5-[1, 2] dithiolan-3-yl-pentanoic …
[引用][C] Prevention of oxidant-induced cell death by lysosomotropic iron chelators
L Persson, J Eaton, U Brunk - 2002 - diva-portal.org
Prevention of oxidant-induced cell death by lysosomotropic iron chelators …