Primary care–based buprenorphine taper vs maintenance therapy for prescription opioid dependence: a randomized clinical trial
DA Fiellin, RS Schottenfeld, CJ Cutter… - JAMA internal …, 2014 - jamanetwork.com
Importance Prescription opioid dependence is increasing and creates a significant public
health burden, but primary care physicians lack evidence-based guidelines to decide
between tapering doses followed by discontinuation of buprenorphine hydrochloride and
naloxone hydrochloride therapy (hereinafter referred to as buprenorphine therapy) or
ongoing maintenance therapy. Objective To determine the efficacy of buprenorphine taper
vs ongoing maintenance therapy in primary care–based treatment for prescription opioid …
health burden, but primary care physicians lack evidence-based guidelines to decide
between tapering doses followed by discontinuation of buprenorphine hydrochloride and
naloxone hydrochloride therapy (hereinafter referred to as buprenorphine therapy) or
ongoing maintenance therapy. Objective To determine the efficacy of buprenorphine taper
vs ongoing maintenance therapy in primary care–based treatment for prescription opioid …
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