Production and characterization of nanostructured lipid carriers and solid lipid nanoparticles containing lycopene for food fortification

A Akhoond Zardini, M Mohebbi, R Farhoosh… - Journal of food science …, 2018 - Springer
A Akhoond Zardini, M Mohebbi, R Farhoosh, S Bolurian
Journal of food science and technology, 2018Springer
In this study, lycopene, was loaded on nanostructured lipid carrier and solid lipid
nanoparticles using combination of high shear homogenization and ultrasonication method.
Effect of applied lipids types, nanocarrier's type and lycopene loading on physicochemical
properties of developed nanocarriers were studied. Particle sizes of developed nanocarriers
were between 74.93 and 183.40 nm. Encapsulation efficiency of nanostructured lipid carrier
was significantly higher than solid lipid nanoparticles. Morphological study of developed …
Abstract
In this study, lycopene, was loaded on nanostructured lipid carrier and solid lipid nanoparticles using combination of high shear homogenization and ultrasonication method. Effect of applied lipids types, nanocarrier’s type and lycopene loading on physicochemical properties of developed nanocarriers were studied. Particle sizes of developed nanocarriers were between 74.93 and 183.40 nm. Encapsulation efficiency of nanostructured lipid carrier was significantly higher than solid lipid nanoparticles. Morphological study of developed nanocarriers using scanning electron microscopy showed spherical nanoparticles with smooth surface. Lycopene was entrapped in nanocarriers without any chemical interaction with coating material according to Fourier transform infrared spectroscopy spectrum and differential scanning calorimetry thermogram. Glycerol monostearate containing nanoparticles showed phase separation after 30 days in 6 and 25 °C, whereas this event was not observed in nanosuspensions that produced by glycerol distearate. Lycopene release in gastrointestinal condition was studied by the dialysis bag method. To evaluate nanocarrier’s potential for food fortification, developed lycopene-loaded nanocarriers were added to orange drink. Results of sensory analysis indicated that nanoencapsulation could obviate the poor solubility and tomato after taste of lycopene. Fortified sample with lycopene nanocarriers didn’t show significant difference with blank orange drink sample except in orange odor.
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