Production of antitubercular depsipeptides via biosynthetic engineering of cinnamoyl units
Z Yang, C Sun, Z Liu, Q Liu, T Zhang… - Journal of Natural …, 2020 - ACS Publications
Z Yang, C Sun, Z Liu, Q Liu, T Zhang, J Ju, J Ma
Journal of Natural Products, 2020•ACS PublicationsTwo new cyclodecapeptides, atratumycins B (1) and C (2), containing substituted cinnamoyl
side chains were generated by converging elements of the atratumycin (3) and atrovimycin
(4) biosynthetic pathways. The structures of 1 and 2 were determined on the basis of
HRESIMS, 1D and 2D NMR data, and X-ray single-crystal diffraction studies. Atratumycin B
(1) is active against autoluminescent Mycobacterium tuberculosis H37Rv, displaying a
minimum inhibitory concentration of 3.1 μg/mL (2.3 μM).
side chains were generated by converging elements of the atratumycin (3) and atrovimycin
(4) biosynthetic pathways. The structures of 1 and 2 were determined on the basis of
HRESIMS, 1D and 2D NMR data, and X-ray single-crystal diffraction studies. Atratumycin B
(1) is active against autoluminescent Mycobacterium tuberculosis H37Rv, displaying a
minimum inhibitory concentration of 3.1 μg/mL (2.3 μM).
Two new cyclodecapeptides, atratumycins B (1) and C (2), containing substituted cinnamoyl side chains were generated by converging elements of the atratumycin (3) and atrovimycin (4) biosynthetic pathways. The structures of 1 and 2 were determined on the basis of HRESIMS, 1D and 2D NMR data, and X-ray single-crystal diffraction studies. Atratumycin B (1) is active against autoluminescent Mycobacterium tuberculosis H37Rv, displaying a minimum inhibitory concentration of 3.1 μg/mL (2.3 μM).
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