Progesterone receptor signaling in uterine myometrial physiology and preterm birth
SP Wu, FJ DeMayo - Current Topics in Developmental Biology, 2017 - Elsevier
Myometrium holds the structural integrity for the uterus and generates force for parturition
with its primary component, the smooth muscle cells. The progesterone receptor mediates
progesterone-dependent signaling and connects to a network of pathways for regulation of
contractility and inflammatory responses in myometrium. Dysfunctional progesterone
signaling has been linked to pregnancy complications including preterm birth. In the present
review, we summarize recent findings on modifiers and effectors of the progesterone …
with its primary component, the smooth muscle cells. The progesterone receptor mediates
progesterone-dependent signaling and connects to a network of pathways for regulation of
contractility and inflammatory responses in myometrium. Dysfunctional progesterone
signaling has been linked to pregnancy complications including preterm birth. In the present
review, we summarize recent findings on modifiers and effectors of the progesterone …