Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor
associated with poor outcome. In this study, we analyzed the prognostic relevance of genetic
alterations, immunophenotypic markers, and microarray gene expression signatures in a
panel of 53 adult T-ALL patients treated in the Eastern Cooperative Oncology Group E2993
clinical trial. An early immature gene expression signature, the absence of bi-allelic TCRG
deletion, CD13 surface expression, heterozygous deletions of the short arm of chromosome …

Abstract 294 T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic
tumor associated with poor prognosis. Over the last decade, microarray gene expression
studies have shown that T-ALL encompasses distinct molecular groups defined by
characteristic gene expression signatures and molecular studies have uncovered major
mechanisms of T-cell transformation and numerous oncogenes and tumor suppressors
involved in the pathogenesis of T-ALL. This molecular and genetic heterogeneity suggests …