Prognostic role of APC and RASSF1A promoter methylation status in cell free circulating DNA of operable gastric cancer patients
I Balgkouranidou, D Matthaios, A Karayiannakis… - Mutation Research …, 2015 - Elsevier
Gastric carcinogenesis is a multistep process including not only genetic mutations but also
epigenetic alterations. The best known and more frequent epigenetic alteration is DNA
methylation affecting tumor suppressor genes that may be involved in various
carcinogenetic pathways. The aim of the present study was to investigate the methylation
status of APC promoter 1A and RASSF1A promoter in cell free DNA of operable gastric
cancer patients. Using methylation specific PCR, we examined the methylation status of …
epigenetic alterations. The best known and more frequent epigenetic alteration is DNA
methylation affecting tumor suppressor genes that may be involved in various
carcinogenetic pathways. The aim of the present study was to investigate the methylation
status of APC promoter 1A and RASSF1A promoter in cell free DNA of operable gastric
cancer patients. Using methylation specific PCR, we examined the methylation status of …
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