Detailed mapping of superposed fabrics and their mineral support allows for reconstruction of the tectonometamorphic evolution of the Ivozio Complex, within the inner portion of the Sesia-Lanzo Zone (Western Italian Alps). The resulting evolution is characterized by a multi-stage structural and metamorphic re-equilibration during Alpine subduction, starting from the pre-Alpine igneous association (Amp0 + Cpx0). The prograde associations begin with S1a marked by AmpI + ZoI which pre-date the growth of GrtI (S1b); successive increase in pressure stabilizes a second generation of Amp + Grt (S1c AmpII + ZoI + GrtII). The growth of prograde lawsonite and omphacite occur during S1d (OmpI + Lws + GrtII + AmpII) within lawsonite-bearing eclogites, while S1e is associated with the break-down of lawsonite, producing the association OmpI + Ky + ZoII + GrtII + AmpII (lws-bearing eclogites); S1d-e stages are associated with AmpII + ZoI + GrtII + OmpI in eclogites. The second generation of penetrative foliation (S2), describing the retrograde evolution, is divided into S2a (AmpII + GrtII + Pg + ZoII) and S2b (Chl + AmpIII + Pg + Ab). The comparison between the reconstructed evolution of the Ivozio Complex and P–T paths inferred in the Southern Sesia-Lanzo Zone suggests a non-uniqueness of the Sesia-Lanzo Zone continental crust, during the Alpine subduction.