[PDF][PDF] Prospective, brain-wide labeling of neuronal subclasses with enhancer-driven AAVs

LT Graybuck, A Sedeno-Cortes, TN Nguyen, M Walker… - BioRxiv, 2019 - scholar.archive.org
Labeling and perturbation of specific cell types in multicellular systems has transformed our
ability to understand them. The rapid pace of cell type identification by new single-cell
analysis methods has not been met with efficient access to these newly discovered types. To
enable access to specific neural populations in the mouse cortex, we have collected single
cell chromatin accessibility data from select cell types. We clustered the single cell data and
mapped them to single cell transcriptomics to identify highly specific enhancers for cell …

[引用][C] Prospective, brain-wide labeling of neuronal subclasses with enhancer-driven AAVs. bioRxiv 525014

LT Graybuck, AE Sedeño-Cortés, TN Nguyen - View at: Publisher Site, 2019
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