Prospective studies on the routine use of a novel multivariant enzyme-linked immunosorbent assay for the diagnosis of autoimmune bullous diseases
N van Beek, C Dähnrich, N Johannsen… - Journal of the American …, 2017 - Elsevier
Background Serologic diagnosis of autoimmune blistering disease (AIBD) usually follows a
sophisticated multistep algorithm. Objective We sought validation of a multivariant enzyme-
linked immunosorbent assay (ELISA) in the routine diagnosis of AIBD. Methods The
multivariant ELISA comprising 6 recombinant immunodominant forms of major AIBD target
antigens, ie, desmoglein 1, desmoglein 3, envoplakin, BP180, BP230, and type VII collagen
was applied in:(1) a cohort of well-characterized AIBD (n= 173) and control sera (n= 130),(2) …
sophisticated multistep algorithm. Objective We sought validation of a multivariant enzyme-
linked immunosorbent assay (ELISA) in the routine diagnosis of AIBD. Methods The
multivariant ELISA comprising 6 recombinant immunodominant forms of major AIBD target
antigens, ie, desmoglein 1, desmoglein 3, envoplakin, BP180, BP230, and type VII collagen
was applied in:(1) a cohort of well-characterized AIBD (n= 173) and control sera (n= 130),(2) …
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