Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts: a putative explanation for why intermittent …
T Bellido, AA Ali, LI Plotkin, Q Fu, I Gubrij… - Journal of Biological …, 2003 - ASBMB
It is unknown why sustained elevation of parathyroid hormone (PTH) stimulates bone
resorption, whereas intermittent administration stimulates bone formation. We show in mice
that daily injections of PTH attenuate osteoblast apoptosis, thereby increasing osteoblast
number, bone formation rate, and bone mass, but do not affect osteoclast number. In
contrast, sustained elevation of PTH, achieved either by infusion or by raising endogenous
hormone secretion with a calcium-deficient diet, does not affect osteoblast apoptosis but …
resorption, whereas intermittent administration stimulates bone formation. We show in mice
that daily injections of PTH attenuate osteoblast apoptosis, thereby increasing osteoblast
number, bone formation rate, and bone mass, but do not affect osteoclast number. In
contrast, sustained elevation of PTH, achieved either by infusion or by raising endogenous
hormone secretion with a calcium-deficient diet, does not affect osteoblast apoptosis but …
[PDF][PDF] Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts
T Bellido, AA Ali, LI Plotkin, Q Fu, I Gubrij, PK Roberson… - researchgate.net
It is unknown why sustained elevation of parathyroid hormone (PTH) stimulates bone
resorption, whereas intermittent administration stimulates bone formation. We show in mice
that daily injections of PTH attenuate osteoblast apoptosis, thereby increasing osteoblast
number, bone formation rate, and bone mass, but do not affect osteoclast number. In
contrast, sustained elevation of PTH, achieved either by infusion or by raising endogenous
hormone secretion with a calcium-deficient diet, does not affect osteoblast apoptosis but …
resorption, whereas intermittent administration stimulates bone formation. We show in mice
that daily injections of PTH attenuate osteoblast apoptosis, thereby increasing osteoblast
number, bone formation rate, and bone mass, but do not affect osteoclast number. In
contrast, sustained elevation of PTH, achieved either by infusion or by raising endogenous
hormone secretion with a calcium-deficient diet, does not affect osteoblast apoptosis but …
以上显示的是最相近的搜索结果。 查看全部搜索结果