Protective effects of aqueous fruit extract from Sea Buckthorn (Hippophae rhamnoides L. Spp. Turkestanica) on haloperidol-induced orofacial dyskinesia and neuronal …

F Batool, AH Shah, SD Ahmed, ZS Saify… - Medical Science …, 2010 - medscimonit.com
Background: Long-term treatment of haloperidol, a neuroleptic, induces neurodegeneration
specifically in the striatum (caudate and putamen), which plays an important role in the
development of orofacial dyskinesia, a putative model of tardive dyskinesia (TD). This study
investigated the protective effects of a concomitant treatment of aqueous fruit extract of Sea
buckthorn (Hippophae rhamnoides L. spp. Turkestanica)(SBT-FE)(40 mg/kg, orally) plus
haloperidol (3.0 mg/kg, ip) administration on an animal model of TD and on striatal neuronal …
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