Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation
Abstract Introduction Visfatin/nicotinamide phosphoribosyltransferase (Nampt), an enzyme
involved in energy metabolism and sirtuins, SIRT1 and SIRT3, which are NAD-dependent
deacetylases, are critical for cellular function. All three either regulate or are regulated by
intracellular NAD+ levels and therefore available cellular energy, important for placental cell
survival and successful pregnancy. This study investigates whether these protective proteins
are involved in the placental pathophysiology of pre-eclampsia (PE) and if they are …
involved in energy metabolism and sirtuins, SIRT1 and SIRT3, which are NAD-dependent
deacetylases, are critical for cellular function. All three either regulate or are regulated by
intracellular NAD+ levels and therefore available cellular energy, important for placental cell
survival and successful pregnancy. This study investigates whether these protective proteins
are involved in the placental pathophysiology of pre-eclampsia (PE) and if they are …
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