The article reports on the protective role of ascorbic acid against lead toxicity in blood of albino mice as revealed by metal uptake, lipid profiles, and ultrastructural features of erythrocytes. Lead is a relatively abundant metal in nature. A biologically nonessential element, the metal finds extensive use in modern times. The build up and transportation of lead in water, atmosphere and sediment results in bioaccumulation of the metal in various pockets of food chain. Despite several published accounts on pathophysiology of lead toxicity and the cure of lead poisoning by sequestering agents the approaches are limited in scope.