Diabetic nephropathy is a common diabetic complication and a primary cause of end-stage renal failure in many parts of the world. Synthetic medications are excellent at lowering blood sugar levels, but they come with a slew of unpleasant drawbacks. To combat this, natural products that may be used as a dietary supplement to prevent diabetic nephropathy are needed. Most medicines that induce nephrotoxicity which exerts toxic effects by one or more common pathogenic mechanisms. Alloxan andStreptozotocin are the two most often used medicines among them. Alloxan and Streptozotocin-induced diabetic nephropathy in rats provide useful models for studying effect of natural product effect. Many researchers have utilised the model to investigate the effects of medications on diabetes. In traditional medicine, natural products such as crude herbals, extracts, polyherbal formulations, herbo-mineral formulations, and others have been used to treat diabetes. In this review, we compiled several natural herbs that are used in the management of Alloxan and Streptozotocin induced diabetic nephropathy with their parameters evaluated.