Senescence-accelerated mouse prone 10 (SAMP10) strain is a model of age-related
neurodegeneration in the limbic forebrain. To investigate changes in protein expression
profiles involved in neurodegeneration, we performed two-dimensional fluorescence
difference gel electrophoresis and compared protein expression in the limbic and non-limbic
forebrains of SAMP10 and control mice at various ages. Among protein spots in which
patterns of aging in expression in the limbic forebrain differed between SAMP10 and control …