Proteomic differentiation pattern in the U937 cell line
The U937 cell line, originally established from a histiocytic lymphoma, has been widely used
as a powerful in vitro model for haematological studies. These cells retain the immature cell
phenotype and can be induced to differentiate by several factors, among which 12-O-
tetradecanoyl-13-phorbol acetate (TPA). Fully differentiated cells acquire the adherent
phenotype and exhibit various properties typical of macrophages. However, in spite of a
great deal of research devoted to the U937 cellular model, the molecular basis of biological …
as a powerful in vitro model for haematological studies. These cells retain the immature cell
phenotype and can be induced to differentiate by several factors, among which 12-O-
tetradecanoyl-13-phorbol acetate (TPA). Fully differentiated cells acquire the adherent
phenotype and exhibit various properties typical of macrophages. However, in spite of a
great deal of research devoted to the U937 cellular model, the molecular basis of biological …
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