Study on the proximate and mineral composition of flesh and other body parts of Synodontis clarias and Oreochromis niloticus was carried out in September, 2012 using standard procedures. The protein content ranged from (31.10±0.92-21.00±0.81%) in the S. clarias while in O. niloticus ranged from (29.80±0.86-20.40±0.73%) both in the head sector and flesh. Concentrations of fats were (10.30±0.81-2.30±0.89%) in S. clarias while in O. niloticus were (8.20±0.73-2.00±0.85%) in the flesh and bones. Fibre values ranged from (2.30±0.92-0.20±0.81%) in the S. clarias and O. niloticus observed to be (1.82±0.86-0.20±0.73%) in head and flesh. Carbohydrate recorded in S. clarias ranged from (42.82±0.81-14.03±0.91) in the flesh and bones while in O. niloticus ranged from (53.20±0.77-36.40±0.85%) in fins and bones. Ash observed was (46.45±0.91-15.48±0.81%) in the fins and flesh of S. clarias while in O. niloticus shows (25.80±0.85-10.00±0.73%) in bones and flesh. Moisture contents recorded in S. clarias was (10.20±0.81-6.10±0.92) while in O. niloticus shows (11.20±0.73-5.70±0.86%) in the flesh and head. Dry matter values observed in S. clarias were (93.90±0.92-89.80±0.81) while in O. niloticus were (94.30±0.86-88.80±0.73%) in heads and flesh. The highest calcium (8.18±0.45) and (8.03±0.49) was recorded in bones and lowest values (0.18±0.71) and (1.00±0.69) in flesh and fins of O. niloticus and S. clarias respectively. The highest magnesium (9.83±0.54) and (9.82±0.71) was recorded in flesh and fins while the lowest (5.43±0.45) and (6.68±0.71) observed in heads of the fish species. Iron observed high (3.45±0.45) and (2.38±0.45) in bones and head while the lowest (0.34±0.72) and (0.68±0.49) in fins and flesh of the O. niloticus and S. clarias respectively. The study showed that the best body parts in terms of proximate and mineral composition of the two fish species were the head, flesh and bones, although there was no significant difference.